The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
But if you could correct that with diet, sleep, and exercise, which you can, yeah, I agree it can. Um, it's hard, but it could be done. Yeah. Uh, then those things aren't going after fundamental pillars of aging because people who eat well, who exercise well, and sleep well still age.
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
Well, the the GLP um drugs uh and SGLT2 I think are interesting. I don't think we have the data right now, but it's definitely again I don't know in people that are You know, if you're obese, I need Yeah. Okay. So, let let me restate the question. If if we if we just took a population of middle-aged healthy individuals and we we could design an experiment where you had the placebo arm, the metformin arm, the rapamy arm, the SGLT2 inhibitor arm, and the GLP1 agonist arm. What is your prediction in length of life or additional years of life given in that six arm study or whatever it is?
Then those things aren't going after fundamental pillars of aging because people who eat well, who exercise well, and sleep well still age.