Semaglutide raises insulin levels slightly in the short term while increasing insulin sensitivity, leading to weight loss.

“one of the arguments against at least the way the carbohydrate insulin model is typically played out is actually given by semiglutid which raises insulin in the short run so one of the things we always you know see when we put patients on this drug is they're going to lose a ton of weight and their insulin levels go up slightly now this tends to resolve over time so for a long enough period of time we tend to see insulin come down but in the short run for about three months we see elevations in insulin and we also know that it's increasing insulin sensitivity”