FDA risk category C includes drugs with adverse effects in animal studies but no adequate human studies, used when maternal benefit justifies the risk; this category includes most drugs (60-70%), such as gabapentin, amlodipine, trazodone, GLP-1 agonists, some SSRIs, and short-term narcotic use.

“Then you go to category C. We have animal studies that show some adverse effects, but no real adequate human studies. Um, and here these are drugs that are supposed to be used provided there's, you know, enough benefit for the mother to justify it. Again, this is most drugs fit in this category, 60 to 70%. So, you have something like gabapentin, amloopene, which is a blood pressure medication. Trazadone for sleep, GLP-1 agonists are in here, uh certain SSRIs or anti-depressants, and even very short-term use of narcotic pain medication.”