For individuals experiencing significant weight loss and improved glycemic control on GLP-1 agonists, the benefits may outweigh negative changes in heart rate and HRV.

“but I would just kind of say in general that yeah if we see these noticeable decreases in HRV and these very noticeable increases in heart rate that's a real sign that the body is is the autonomic nervous system is being adjusted in an artificial way and that probably is not a good thing in the long run”

“clearly for some people whatever unknown exists around these drugs is worth it right like if you're if an individual you know goes from being 250 lb to 200 lb and having a hemoglobin A1c of 7% to 5.5% that is so positive for them”

“if it raises your heart rate that much and lowers your heart rate variability is there is it is it doing so is that are we picking up a signal that is just a niche representation of appetite suppression via the Vegas nerve or is it actually playing a role in the parasympathetic sympathetic dials I would imagine it's it's got to be I mean to move it that large 10 beats is a fairly significant amount I would can't imagine that's not having an actual effect on our ability to regulate ourselves effectively we're probably in a more sympathetic State all the time which is going to have a cost”

“I would imagine it's it's got to be I mean to move it that large 10 beats is a fairly significant amount I would can't imagine that's not having an actual effect on our ability to regulate ourselves effectively we're probably in a more sympathetic State all the time time which is going to have a cost”