For individuals experiencing significant weight loss and improved glycemic control on GLP-1 agonists, the benefits may outweigh negative changes in heart rate and HRV.

“if an individual you know goes from being 250 lb to 200 lb and having a hemoglobin A1c of 7% to 5.5% that is so positive for them that I think it justifies whatever unknown exists around these drugs if there's no other way they're going to achieve that benefit”

“clearly for some people whatever unknown exists around these drugs is worth it right like if you're if an individual you know goes from being 250 lb to 200 lb and having a hemoglobin A1c of 7% to 5.5% that is so positive for them”

“if it raises your heart rate that much and lowers your heart rate variability is there is it is it doing so is that are we picking up a signal that is just a niche representation of appetite suppression via the Vegas nerve or is it actually playing a role in the parasympathetic sympathetic dials I would imagine it's it's got to be I mean to move it that large 10 beats is a fairly significant amount I would can't imagine that's not having an actual effect on our ability to regulate ourselves effectively we're probably in a more sympathetic State all the time which is going to have a cost”

“I would imagine it's it's got to be I mean to move it that large 10 beats is a fairly significant amount I would can't imagine that's not having an actual effect on our ability to regulate ourselves effectively we're probably in a more sympathetic State all the time time which is going to have a cost”