Rhonda Patrick· PhD
The dark side of GLP-1 drugs—can they trigger depression?
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We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
The dark side of GLP-1 drugs—can they trigger depression?
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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The risk of suicidal behavior doubles and the risk of major depression triples in people who were on the drug for up to two years on any dose of it or the high dose on the high on the currently used um wiggoi dose which is the higher dose which is common. Um so not a micro dose. Uhhuh. Right. Yeah. Yes. Well, my view of this is I don't know the mechanism. I don't know what the central effect is of this drug but as much one way and this is my own kind of philosophical view. We we rejoice in the fact that this drug has helped me it's reduced my cravings for junk food let's say and we would say that's a a wonderful outcome. What if in the midst of reducing the cravings for junk food, it reduces their cravings for everything they enjoyed? Where you hear, this is anecdotal now. People lose interest in their old habits. A gal, the gal who used to like walking around the block with her girlfriends doesn't really want to go anymore. The guy who used to like getting on and playing video games, he doesn't want to do that anymore. They don't want to a couple, they don't go play pickle ball with their friends anymore. Whatever. Maybe what we describe as improved eating control is actually just a reduced joy for life in general. But the regardless of the mechanism or the philosophy behind it, the evidence is extremely clear. The major depression risk, people were three times more likely to have clinically diagnosed major depression. And again, twice more likely for suicidal behavior and twice as likely. It was like 106% increased risk of anxiety. And this is after the weight loss and after being on the drug. And yeah, that's right. It was two years on the drug.