Low glutathione status, worsened by reduced insulin sensitivity and glycation damage, creates a cycle that exacerbates insulin resistance and further depletes glutathione.

“there's sort of a vicious cycle where you need insulin to synthesize glutathione and as you lose insulin or insulin sensitivity you start getting more glycation damage because glutathione protects against that and you're you basically you lose glutathione the glycation damage makes the insulin sensitivity worse you lose more glutathione that makes you insulin sensitivity more worse etc etc just goes kind of spirals on”