Somatostatin acts as a negative feedback mechanism on growth hormone production.

“so if someone is just taking exogenous growth hormone and um how long would they need to take it before they would start to compromise their own ability to make endogenous growth hormone once they came off um I think it's pretty quick like igf-1 elevations are not instant like in the serum you would see GH spikes in a matter of minutes like it's very transient in N your system very short halflife but the downstream igf-1 conversion can increase over days and then stay elevated for days”