Gliadin can trigger immune reactions leading to a leaky bowel in individuals with genetic susceptibility, as seen in celiac disease.

“Let's talk about celiac disease, right, celiac disease mediated by proteins that are present in certain crops. For example, gliadin is the major protein that is a part of bread, what makes our dough sticky, and what makes our bread tasty. And in individuals that suffer from a genetic susceptibility to develop immune reactivity to this protein, then a cascade of immune reactions occurs that leads among many other changes to a leaky bowel or to a leaky gut which contributes to disease state in the celiac patients.”