Leaky gut allows endotoxin (LPS) to enter the bloodstream, triggering an inflammatory cascade via the NF-kappaB pathway, which can affect the brain.

“when your gut is leaky it allows for one of the most potent stimulators of the immune system endotoxin that comes from gram-negative bacteria in the in the large intestine to get into your bloodstream and it triggers an immune response but it turns on actually and you know about this pathway the nf kappa v pathway so it turns on an inflammatory cascade that not only um gets your white blood cells all agitated but it even goes to your brain and turns on that inflammatory cascade in your brain”