When the gut microbiome is starved of fiber, bacteria release lipopolysaccharide (LPS) endotoxin, which triggers the body to produce more LDL cholesterol as a protective response.

“when you're starving your gut microbiome of this fiber, and the bacteria starts to break down the mucin and gut cells possibly aren't making as this much mucin, then when those immune cells become in contact with bacteria. They start to kill it because that's what they're programmed to do. Immune cells bacteria, well, that's, I'm going to kill it. So then what happens is they kill bacteria, this releases lipopolysaccharide endotoxin and what happens when you release endotoxin, it gets released in the bloodstream while your body has an adoptive response to it. It produces more cholesterol the LDL, and the reason for that is because there is binding sites the LDL receptors on the LDL and also on HDL cholesterol. Bind endotoxin is the way stopping it up to protect your body. You don't want to go into sepsis, and so you're producing more cholesterol that's why when you're in inflammed state you produce more cholesterol.”