Peter Attia· MD
in serum free without stimulation they had less activation and less proliferation half of normal suggesting yeah that's the mutation that's the function when he incubated them with growth hormone it totally switched
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
in serum free without stimulation they had less activation and less proliferation half of normal suggesting yeah that's the mutation that's the function when he incubated them with growth hormone it totally switched
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so I asked so what's the igf-1 level and he showed it slower
it took this lymphoblast and he incubated them with and without growth hormone and something really interesting happened when they were not incubated with growth hormone the phosphorylation of this receptor the activity of this receptor was lower as as we thought it would be because they have deletion of an axon mm-hmm but when he incubated with growth hormone it was almost like an amplifying switch they were phosphorylated three times as much the same was with proliferation proliferation was lower and with growth hormone was increased