Paul Saladino· MD
the problem with you know compounds that are suspected endocrine disruptors is that they don't tip they don't follow the typical toxicity you know curve which is the dose makes the poison one of the problems I think with endocrine disruptors which is made them very hard to not only study but it's made them tricky to to regulate and obviously manufacturers love this is that they follow a very unusual sort of toxicity curve so with most compounds I mean a high enough dose of anything becomes toxic right oxygen water you drink enough water fast enough it can kill you but and this is certainly true for you know compounds heavy metals for example arsenic that the dose makes the poison endocrine disrupters what makes them so treacherous is that they can have what's called a non monotonic dose curve so they might become toxic in a very high dose but then they could go quiet potentially in the body at sort of a more moderate dose and then at a very low dose for whatever reason they might become actually biologically active