The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Clomid first it's a serm negative feedback to the estrogen receptor the problem with Clomid is the following we get a discrepancy effect and this is what happens you get a very nice bump in the testosterone level that's true but roughly 40% of patients say I have no desire for sex I have no erections I don't feel any desire because the way the Clomid works it blocks estrogen receptor centrally men need estrogen you need EST for libido and sexual function
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so they have these beautiful 800 900 levels no you take that same patient and put them on exogenous testosterone at 800 he says it's working so the way Clomid works is that it blocks and so that mechanism is not conducive for many men
Clomid first it's a serum negative feedback to the estrogen receptor the problem with Clomid is the following we get a discrepancy effect and this is what happens you get a very nice bump in the testosterone level that's true but roughly 40 of patients say I have no desire for sex I have no erections I don't feel at any desire because the waist this Clomid works it blocks estrogen receptor centrally men needed estrogen it is critical you need Estes for libido and sexual function
It interacts with the estrogen receptor in either a positive or negative way in that it could stimulate activity or prevent estrogen from binding to it and interacting and providing estrogen related activity in certain tissues and it's selective in the way it does this. So Clomid is has anti-estrogenic activity in the hypothalamus. So it kind of tricks your brain into thinking it's estrogen deprived. So the response to that is we have low estrogen so we need to make more testosterone to aromatize into estrogen. So you uptick your G&R output to the pituitary which will increase LH and FSH which increases test and then you can sort of intervene with that compound to trick your body to make more tests I guess is the best way to put it.