Peter Attia· MD
its primary mechanism of action is that it is there to tell the brain that you don't have enough fat
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
its primary mechanism of action is that it is there to tell the brain that you don't have enough fat
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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leptin is a signal that says there's not enough energy and that's what should really trigger the response so in that sense it's not surprising that leptin isn't doing the opposite it's not surprising that high leptin doesn't make you want to stop eating it's who cares nature wouldn't have cared about that but it certainly would care if leptin gets too low that should be a screaming signal to go and eat resist that resist that sign
we know that leptin is very good to defend against the loss of weight when it becomes extreme but it doesn't work on the other side of the equation when you creep up you know with your weight because you become leptin resistant and you know your leptin is not telling you stop to eat
leptin is a signal that says there's not enough energy and that's what should really trigger the response so in that sense it's not surprising that leptin isn't doing the opposite it's not surprising that high leptin doesn't make you want to stop eating it's who cares nature wouldn't have cared about that but it certainly would care if leptin gets too low that should be a screaming signal to go and eat