The original conclusions of the Women's Health Initiative regarding hormone replacement therapy have largely been overturned.

“it's hands down the biggest screw-up of the entire medical field in the last 25 years now again it's possible in the next hour I'll think of nope there's a bigger screw up another another Giants yeah but but I don't think I will I I'm pretty confident that I won't be able to think of a bigger Act of incompetence then what happened with the Women's Health Initiative in the late 90s and early 2000s which is effectively the study that turned the entire medical field off hormone replacement therapy for women”

“so here you have basically a non-event that has most people panicked senseless most women panicked senseless when confronted with taking hormones during the perimenopausal period and yet at the other end of that Spectrum we have a treatment that has more than a log fold benefit in the other direction I.E in reducing risk and I wish I wish people would just allow their attention to be allocated proportionate to the size of the impact”

“I think basically every conclusion of the original Women's Health Initiative has been turned over”

“so many women are so petrified of hormone replacement therapy because of this awful you know study the Women's Health Initiative which was completely misinterpreted”