Cortisol acts transcriptionally, and long-term, low-level elevations are a concern.

“cortisol like we know that it will impede muscle protein synthesis but again that is cortisol acts transcriptionally like testosterone it is actually a steroid hormone in fact people get confused because they're like well he got a steroid steroid injection before his you know tennis match and people like they're not test just not injecting them with testosterone they're giving them cortisol so he can go out and play because it reduces inflammation in that particular area well cortisol is more of a long-term hormone it's acting transcriptionally so it's what you need to be worried about are long-term low-level elevations in cortisol”