Peter Attia· MD
Leptin is a hormone is it made in the adipocyte it is yeah it's made in the adipocyte and secreted in proportion to body fat mass so the more adipose tissue you have the more leptin you have however it's also strongly impacted by short-term energy balance so if you if you let's say cut your calories by 25 for a couple of days you're going to see a drop in leptin that is disproportionate to your amount of fat mass