Paul Saladino· MD
Androgen receptors are necessary for Testosterone, DHT and other androgens to have an effect at the nuclear level, gene transcription.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
Androgen receptors are necessary for Testosterone, DHT and other androgens to have an effect at the nuclear level, gene transcription.
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testosterone binds to an androgen receptor DHT also binds to an androgen receptor it just does so in a way more potent fashion and this happens inside the nucleus of a cell and that's what affects transcription
This new complex of testosterone or DHT bound to the AR makes its way into the nucleus where it acts as a transcription factor binding to DNA and uh imparting on it effectively uh trans transcription translation. That's how we make stuff. It's how we make proteins. So that's how it impacts muscle protein synthesis.
these hormones work by binding to Androgen receptors and the testosterone Androgen receptor complex has to make its way into the nucleus where it impacts trans descrition factors