Tonkat Ali may increase testosterone by inhibiting the feedback loop at the hypothalamus level, acting as a selective estrogen receptor modulator.

“One being minor uh serum activity potentially. And this is more speculative. Serum is like a selective estrogen receptor modulator. So something that binds to estrogen receptors and either like positively or negatively modulates them in selective tissues. So there are certain tissues where it would be more favorable to have a selective inhibition of certain hormones versus others who would be detrimental. Like you wouldn't want to inhibit estrogen's activity in bone for example because that would cause bone degradation. Um having an inhibition at the hypothalamus level level may depending on the person help increase testosterone via the inhibition of that feedback loop. Now I don't necessarily think it is a serum. That's just like the tertiary potential mechanism and it is speculative.”

“Tonat Ali another very notable one. This is one that um works through a different mechanism. It seems to be a bit more speculative how it works, but it seems to do a few things potentially. One being minor uh serum activity potentially.”