In mice, castration causes prostate regression through loss of luminal cells, which can regrow the prostate upon reintroduction of testosterone or DHT.

“if you castrate a mouse all of the luminal cells post maturity yes you develop a normal prostate and you castrate a mouse or a rat with the prostate it will regress and think about it like just like a plant in the middle of a drought right it looks dead but there's roots that are still alive okay those roots that are still alive in the prostate are predominantly basil cells if you give that prostate back its growth uh fuel testosterone or DHT um then it will regrow a new prostate and the basil cells uh will begin to repopulate and you'll get also so in a proliferation of these luminal cells that will then form the big bulky meaty prostate that we think about”