In men treated with androgen deprivation therapy followed by testosterone therapy, PSA levels rise until saturation is reached.

“the tricky part for me is when patients come to me after radiation therapy because they've been given Android deprivation therapy testosterone is 50. and their oncologist spent all this time taking away the testosterone that's right and when you get it from 50 past 250 you're going to see that rise until you hit saturation and so the oncologist says what are you doing patient says what's going on I have to set the expectation it's going to rise it's going to Plateau I just have to have that understanding with you based on the saturation model”