Peter Attia· MD
I really think that IGF should be cycled between high and low and for example like when I did my fast after seven days my IGF was probably you know at the 5th to 10th percentile and it might rebound to the 80th percentile when I'm not fasting and so I think it's you know I think epidemiology mostly sucks especially like epidemiology that is involving an intervention like people who do X get Y I think that epidemiology is absolutely the worst the next layer of epidemiology that's like less shitty is like looking at IG F levels and contrasting it with disease because at least there you've simplified a variable you're not trying to figure out like did those people eat more eggs or less eggs like that becomes a separate question and I think based on the epidemiology there's you know there's a there's a u-shaped mortality mortality curve with IGF except it's very skewed so it's not even a perfect you and I'm having a hard time being convinced by anyone including proponents of very low IGF that an IGF outside of the range of about the 60th to 80th percentile is anything but optimal