In women aged 50-59, estrogen alone showed signals of benefit for heart disease, heart attack rates, and all-cause mortality.

“especially with estrogen alone the women in their 50s the youngest women in study were 50 to 59 those women tended to do quite well in terms of heart disease and heart attack rate compared to the women on Placebo there was a signal there for benefit also a signal there for favorable outcomes in terms of all cause mortality”