Loloestrin, containing norethindrone and a low-dose ethinyl estradiol, is favored for its slightly more androgenic progestin, which can blunt the increase in sex hormone-binding globulin and is well-tolerated, though it may cause more bleeding.

“Loestrin? — I was just about to say that's my favorite. — Yeah. So, I use Lolo estrin a lot. — Lolo estrin is norone progesterine. The reason why I like Norah syndrome is it's a little bit more androgenic. The more androgenic the progesterine, the way the it has the ability to blunt or mitigate the increase in sex hormone binding globbulin. Again, I'm talking about pills from a sexual health perspective. There's lots of other ways you could view this, but today this is my angle. And so, when you think about a super lowdose ethanol estradi, low side effects, — plus a, you know, slightly more androgenic progesterine, you then can have a, you know, blunting of the increase in sex hormone binding globulin. less likely to gobble up all those extra androgens and patients tolerate it really well. Side effects are there's more bleeding because of the low ethanol estradi.”