Peter Attia· MD
HRT reduced the incidence of hip fracture by about one and a half percent in absolute terms that's remarkable yes there was the benefit for hip fracture and there were benefits for in other cancers as well
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
HRT reduced the incidence of hip fracture by about one and a half percent in absolute terms that's remarkable yes there was the benefit for hip fracture and there were benefits for in other cancers as well
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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So, the Women's Health Initiative, which was, you know, published over 20 years ago, was a seven-year study or so looking at the administration of hormone replacement therapy on post-menopausal women. ... in that study, there was no ambiguity that the fracture risk was decreased in the women taking HRT. However, that study came to what I believe is an erroneous conclusion, and I think what many people now believe is an erroneous conclusion, that the risk of breast cancer and cardiovascular disease went up.
For symptomatic perimenopausal women under 60, hormone replacement therapy reduces all-cause mortality.
The breast-cancer risk attributed to HRT in the original WHI trial was overstated and the timing window matters most.