The pathophysiology of hypertension has not yielded clinically useful insights in the last 30-40 years.

“the last 30 or 40 years there have been almost an infinite number of basic science studies on hypertension and when you were in medical school and even before that when I was in medical school we talked about pathophysiology of hypertension and what strikes me is we don't talk about the pathophysiology of hypertension anymore but the basic science goes on in rats which is healthier than ever and there isn't anything I know of that's come out of that basic science that's been clinically useful in the last 30 years”