Uric acid reduces endothelial nitric oxide by binding to it, decreasing L-arginine uptake, and potentially blocking endothelial nitric oxide synthase.

“uric acid will reduce endothelial nitric oxide through the inhibition of nos or what mechanism it does it through multiple mechanisms one is it removes nitric oxide directly by binding to it another is it decreases the uptake of of l-arginine which is used to make nitric oxide there's some in some models that seems to be blocking the endothelial nitric oxide synthase”