High blood pressure can cause endothelial walls to be subjected to mechanical pressures they were not designed for, leading to extravasation and cell adhesion, compromising microcirculation.

“these endothelial walls are now subjected to mechanical pressures that they were not designed to do and you have extravasation and you have cells and normally are only engage when we have like a hemorrhage like the platelets to try to coagulate now they start sticking to these endothelial walls and compromising some of the micro circulation as a consequence”