The SPRINT trial achieved blood pressure targets, with the intensive arm reaching approximately 123/82 mmHg and the standard arm reaching approximately 137 mmHg systolic.

“so the NIH designed a study to prospectively evaluate whether treating people to these two different goals and these were aspirational goals that whether that resulted in a change in outcomes and so they randomized these people again the doctors were given leeway as to which agents to use”

“there were real issues right there was a greater increase in the risk of Falls and Syncopy and I think even in the risk of significant kidney dysfunction it was all reversible but it was all there”

“clearly people got to the two goals that they were assigned to randomly it was obviously not blinded because you couldn't be blind to your blood pressure uh but they got to the two goals so the people assigned to the more aggressive 120 over 80 got to like 123 over whatever it was 82 and the people into that 140 over 90 were more like 137”

“this is not a Pharma sponsor sponsored trial this is an NIH sponsored trial the government sponsored trial and was agnostic to different agents right I mean it was not about the the Physicians who enrolled patients in the trial had had access to almost any therapy during that trial so this was not about sort of proving the the benefit of one drug over another”