Gut disruption ('leaky gut') can trigger the immune system, leading to cytokine release and mitochondrial dysfunction.

“the other piece of this that kind of ties it all together is the gut microbiome piece and I think that I think what's happening for a lot of people as they're getting gut disruption right there getting leaky gut and this is of course like a colloquial term but I think that my opinion is that many plant foods many plant antigens are causing disruption of the gut barrier and then the the immune systems getting triggered its releasing cytokines which can then lead to mitochondrial dysfunction”