Rhonda Patrick· PhD
What exercise seems to do is it activates IL6 like crazy, but it doesn’t activate IL1 or TNF. If you pull out people’s blood cells and stimulate them, you actually see reduced release of TNF and IL1.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
What exercise seems to do is it activates IL6 like crazy, but it doesn’t activate IL1 or TNF. If you pull out people’s blood cells and stimulate them, you actually see reduced release of TNF and IL1.
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the more intense the the exercise stimulus, you're in you're actually generating inflammatory compounds. IL is 6 being like the big one and and that IL6 is is actually um signals to, you know, have this anti-inflammatory response.