The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
so then when you turn the clamps off SE let's just say we ran this for 72 hours we've made them functionally diabetic turn the clamps off how many hours or days do that what would you predict I would predict uh probably within 24 to 48 hours they would return to normal cuz we did this acutely
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you took normal volunteers y who had a fasting insulin of eight yep and they're lean healthy okay and you simply infused insulin in them presumably with glucose oh yes of course on the clinical research center where we can monitor keep the glucose perfectly constant we're not letting the glucose change so person shows up insulin eight glucose is 90 you do a ug glycemic clamp where you bring insulin up only by one and a half per one and a half X much less than would be when you eat a meal exactly not even a post pral bump but now it's constitutively sitting there at 20 yeah and you've obviously had to bring glucose you had to infuse glucose to maintain ug glycemia correct did you say that in 4 days 48 to 72 hours these people are as insulin resistant as type two diabetics
we took normal healthy lean kids 18 25 years of age and we uh gave them we put them on the clinical Research Center uh for uh 3 days and we gave them a very very low dose uh of insulin infusion and we raised their fasting insulin from eight which is what a normal person would be to 20 which is really quite low and within 48 to 72 hours they were as insulin resistant as a type 2 diabetic patient
we took normal healthy lean kids 18 25 years of age and we uh gave them we put them on the clinical research center uh for uh 3 days and we gave them a very very low dose uh of insulin infusion and we raised their fasting insulin from eight which is what a normal person would be to 20 which is really quite low and within 48 to 72 hours they were as insulin resistant as a type 2 diabetic patient
turn the clamps off SE let's just say we ran this for 72 hours we've made them functionally diabetic turn the clamps off how many hours or days do that would predict uh I would predict uh probably within 24 to 48 hours they would return to normal cuz we did this acutely
we took normal healthy lean kids 18 25 years of age and we gave them a very very low dose uh of insulin infusion and we raised their fasting insulin from8 which is what a normal person would be to 20 and within 48 to 72 hours they were as insulin resistant as a type 2 diabetic patient