Models using exogenous insulin to induce insulin resistance in mice show that the body never gets a break from insulin signaling.

“the models that do it use exogenous insulin as would a type 1 diabetic and because you can never get your level of control good enough unless you're on ketogenic diet that's the different matter there uh as a type one diabetic but you can never get your control good enough that your body gets a break from the uh insulin signaling it's right at the time whether you've eaten or not”