A patient requiring a higher insulin level (e.g., 90 IU) to clear glucose compared to another patient (e.g., 30 IU) may be at higher risk of developing hyperinsulinemia and future struggles with glucose disposal.

“the hypothesis would be that the patient with hyperinsulinemia is now demonstrating I mean that's basically a harbinger of the first one who's going to struggle with glucose disposal that would be my hypothesis is the one who needed 90 units of insulin to dispose of glucose with the same efficacy as the person who needed 30 is sooner rather than later going to have a harder time disposing of glucose”