In type 2 diabetes, the pancreas requires high insulin levels to clear glucose, and insulin resistance in the liver leads to overproduction of glucose.

“not only are they insulin resistant where they just need a boatload of insulin which is made by the pancreas to get glucose out of the circulation but now that system's not even working well and now they're not getting glucose into the cell so now their glucose level is elevated and even though it's continually being chewed up and used up because again the brain alone would account for most of that glucose disposal the liver is now becoming insulin resistant as well and now the liver isn't able to regulate how much glucose to put into circulation and it's overdoing it”