The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
so hyperinsulinemia induces insulin resistance this is wait a second why is that the case so what insulin does is it downregulates the insulin signaling transduction system so that insulin when it binds to its receptor and then it activates irs1 and pi3 kinas and akt that system is down regulated by hyper insonia
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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so what insulin does is it downregulates the insulin signaling transduction system so that insulin when it binds to its receptor and then it activates irs1 and pi3 kinas and akt that system is downregulated by hyper inssia
it's the direct effect of insulin downregulating the insulin signaling system and probably other distal metabolic within the cell uh as well