Drinking a diet beverage containing sucralose with carbohydrates or other foods is more metabolically harmful than drinking a diet beverage with sucralose alone.

“there is a possibility you would not escape the way that sucralose and other artificial sweeteners will affect the communication between your gut microbes but there's a possibility that you could have a Diet Coke in the middle of the day with nothing else no calories no carbohydrates and that may not be as harmful to your metabolism as drinking a diet coke with a I don't know whatever you want to eat a piece of toast a piece of fruit a hamburger anything with carbohydrates in it with that sucralose containing beverage or food is going to mess up your body's connections between sweetness and present calories”

“and again sucralose plus carbohydrates create massive problems in humans according to Dana's small study”

“you must avoid artificial sweeteners they're horrible for you but you should especially avoid artificial sweeteners like sucralose when they're present with sugars in things like Monster Energy”

“when drinks containing sucralose and carbohydrates were given to humans seven drinks over two weeks their insulin signaling their glucose tolerance got completely messed up”

“there are also studies where sucralose is consumed with other carbohydrate-containing Foods suggesting that this artificial sweetener May disrupt normal insulin signaling and glucose tolerance in your body that is a bad thing that is how you eventually become pre-diabetic”

“when you drink something with sucralose along with any carbohydrate containing foods there's good evidence in humans that is going to cause increased insulin and increase glucose leading to pre-diabetic type physiology”