Physiological glucose sparing occurs when liver and muscle cells have a reduced ability to uptake glucose from the blood, even when blood glucose and insulin levels are normal.

“the second type of we'll call it glucose sparing slash glucose refusal slash glucose from injection is what's considered to be physiological glucose parent which is the reduced ability of liver and/or muscle cells to uptake glucose from the blood in a state in which you are not hyperglycemic and you are not hyperinsulinemic meaning your blood glucose is well controlled your insulin levels are low but even despite two the two of those it goes both being good things muscle and liver tissue is having a difficult time responding to small pause you there therefore cannot take us up”