Pioglitazone improves mitochondrial dysfunction by activating PPAR-gamma and influencing flux through the mitochondrial pyruvate carrier.

“is there anything that improves mitochondrial function more than aerobic exercise training pitzone the drug how so I can't get people to use which is a phenomenal it uh by activating P power gamma uh it it does a lot of good things and one of the important things that it does it has a huge effect to improve mitochondrial uh dysfunction uh and it has Direct effects it also works on the it works directly through P par gamma to do this and it also binds directly to the mitochondrial pyro carrier uh and that uh influences uh flux through the uh through the you know the the mitochondrial uh chain”