Peter Attia· MD
so we again these people are don't have diabetes or pre-diabetes right they're they're they're this could be a healthy person who's not active exactly and this is what unfortunately this being the model in in most research papers out there comparing the unhealthy with a sedentary healthy individual right I've been pushing for for for years that the model should not be the the healthy sedentary individual because that that is the intervention you know as humans we're meant to walk or to exercise so we need to look at Perfection to understand imperfection the intervention of of of of human evolution has been becoming sary you know and in fact I had you know a hard time to to to get IRB you know to to to start the study I have a hard time with the committee to convince them that using active people as the gold standard to understand imperfection that's the way to go but anyways what we see is that these people already they don't have Clinic uh but yet they have a significant they don't they don't have clinical signs clinical symptoms sorry they're not they're not clinical symptoms they're the healthy sary individuals but um um so they're they don't they don't have insulin resistance and they don't have done regulation of glut for Transporters even hyper insulinemia do they have even are they hyperinsulinemic when challenged with the glucose tolerance test these people they have no symptoms they haven't reported any glucose trance test test that is abnormal normal people um and then they have a significant disruption in in this mandri per carrier so which might mean that the the the first door that might be jammed is is that entrance of pyro inside mitochondria most of the research in diabetes has done more at the peripheral level if you will glucose levels more at the surface levels of the cell the glute for the insulin resistance the pancreas releas of ins better cells Etc but what's the fate of glucose once enters the cell right and this is what we're looked into this so and the Fate is pyu but what's the fate of pyu as you said very well does it enter the mandri or is shutle to or reduced lactate so I I I think that this is important to see because it could be a marker down the road because again these people don't have clinical symptoms yet they have a significant and disregulation in their glucose metabolism so could the this be 10 15 years ahead of clinical symptoms and insulin resistance