Insulin resistance is an antioxidant defense mechanism where a cell signals it does not want more metabolic substrate due to caloric overload.

“insulin resistance is an antioxidant defense mechanism and that was one of the very formative papers that i read very very early on in the um when i was developing the ideas for the proton series was that engine resistance is the way that a given cell says no and in that paper they go through three or four different types of insulin resistance and they're very consistent that all of them overload all of them generate reactive oxygen species that's the mechanism of engineering resistance”