Treatment with pioglitazone in diabetic patients significantly improved myocardial blood flow, myocardial and skeletal muscle insulin sensitivity, ejection fraction, and measures of systolic and diastolic dysfunction.

“we took people who had diabetes uh and we treated them with pitone and then using NMR very very sophisticated techniques what we showed is pitzone markedly improved Mar cardial blood flow now these numbers are going to blow your mind away Mar cardial insulin sensitivity with pet and fluid deoxy glucose improved by 75% your heart we showed this before is severely insulin resistant I came pretty damn close to normalizing insulin sity in your heart now since we're doing the insulin clamp with Trad glucose you can track it 74% Improvement in skeletal muscle insulin Sensi exactly the same if you look at ejection fraction it went up by 5 to 10% not down it went up if you look at every measure of diastolic dysfunction e over a e over e Prime LV Peak filling pressures Etc Cardiology people understand this the point is whether you're looking at systolic function or diastolic function it all got better”