Peter Attia· MD
I think the arrow of causation goes both ways which means it's it's sort of a vicious cycle each is making the other words
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
I think the arrow of causation goes both ways which means it's it's sort of a vicious cycle each is making the other words
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is the hyperinsulinemia as a result of muscle insulin resistance let me clarify that muscle insulin resistance which leads to peripheral hyperinsulinemia which is accompanied by portal vein hyperinsulinemia which leads to what you're about to tell us is that the order in which you think this occurs i do as i say this is what we see in our volunteers as we march through the progression in different stages we don't see liver abnormalities in these young 20 year olds it's all muscle and maybe a little bit of the fat cell which we'll come to at the end but it's the muscle there's no alterations in the liver until they get fatty liver once they get fatty liver then we see both insulin resistance in liver and insulin resistance and muscle
take you through the progression from how you just go from insulin resistance and muscle to fatty liver and insulin resistance in the liver and then progress to type 2 diabetes