The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
when you're doing a you glycemic hyperinsulinemic clamp as the name implies you're in a hyperinsulinemic situation you're the first thing they do in that in that laboratory procedure is they give you a super oficio logical dose of insulin to max out insulin receptor capability
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in the case of a you glycemic hyperinsulinemic clamp you know you know they might be injecting glucose and insulin into a vein right
the test I think still has a lot of validity because it's used as in a measurement of maximal glucose uptake and that measurement of maximal glucose uptake I think has a lot of value in the research community because it gives insight into how the muscle and liver are actually operating when they're given a super physiological dose of insulin
I went up to Stanford and did a an insulin suppression test which is along with the you glycemic clamp really the gold standard for measuring measuring insulin sensitivity
well obese people are very insulin resistant in terms of muscle glucose uptake
I actually developed the gold standard technique which is the insen clamp technique to look at this