Pioglitazone is associated with weight gain, which correlates with improved A1c, insulin sensitivity, beta cell function, blood pressure, and HDL cholesterol, and decreased triglycerides.

“pitone causes weight gain okay now here's the problem and it'll become very obvious you know we we talk about these paradoxes the more weight gain the the greater the drop in A1c the more weight gain the greater the Improvement in insulin sensitivity and is it fat gain specifically no oh I'll I'll come back to that in a second okay uh it is fat weight gain and I also believe muscle weight gain okay uh uh the more weight gain the greater the Improvement in beta cell function the more weight gain the greater the drop in blood pressure the more weight you gain the greater the drop in triglycerides the more weight you gain the rise in Greater the rise in HDL cholesterol sounds like terrible drug right so here's another one of those paradoxes okay so why would weight get we know if you overeat and gain weight that's a disaster but with pitzone the more weight you gain everything gets better”