Peter Attia· MD
if you lower the FFA and we did this for 12 days we did in both obese people and in diabetic you markedly improve insulin sensitivity in the muscle if using MRI you can measure muscle fat goes down dramatic ially and and correlates with the Improvement in insulin sensitivity uh we also measured ATP generation because there's this uh issue is this clearly mitochondrial dysfunction if you're a diabetic that that's unequivocal the controversy is is the mitochondrial dysfunction causing the insulin resistance or is the insulin resistance causing the mitochondrial dysfunction so in this study uh that we did when we lowered the FFA uh and lowered the muscle uh lipid uh content we saw uh about a 50% Improvement in ATP generation mitochondrial ATP generation so at least this says that part of the mitochondrial dysfunction is secondary to the lipotoxicity and insulin resistance