The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
and when the adipocytes are over full they begin then they begin releasing palmitate which signals to everything else to become insulin resistant which is basically one of the causes of insulin resistance in type 2 diabetes
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when the adipocytes get over full i think especially the visceral adipose tissue we get a release an inadvertent release of fats and the inadvertent release of those fats is then signaling to the rest of the body hey become insulin resistant
and the inadvertent release of those fats is then signaling to the rest of the body hey become insulin resistant but it's a pathological situation because there is energy overload there's energy everywhere there's high glucose high insulin high free fatty acids because the adipocytes are poisoned with too much linoleic acid they have grown so big yes that they cannot possibly hold it anymore they're just leaking it
this is the free fatty acids that i was talking about fat cells get overly full they spew out fat molecules i've talked about this in the past those fat molecules break insulin signaling and glucose handling in the rest of the body this is metabolic dysfunction