In insulin resistance, immune cells like T-cells, dendritic cells, macrophages, and NK cells may not respond effectively to inflammation or infection.

“More evidence that insulin resistance is a huge driver of worse COVID outcomes.”

“but when we get systemic insulin resistance during times of inflammation or during times of again I guess if we're talking about diabetes it would be metabolic dysfunction then cells are not responding to insulin as well and the signaling from insulin at the level of the cell specifically in this case at the level of immune cells is significant impaired”

“when we are insulin resistant most of the cells of our body become insulin resistant it's not just our liver or our muscles that become insulin resistant I think that what we see in diabetes is that we have immune cell insulin resistance”

“if the T cell or the dendritic cell or the macrophage or the NK cell is insulin resistant they're not going to respond as well in inflammation or infection”

“you can imagine how in a situation of insulin resistance if the T cell or the dendritic cell or the macrophage or the NK cell is insulin resistant they're not going to respond as well in inflammation or infection so I know that was really fascinating and speaks to the idea that insulin resistance in people with Co bid could be really bad because your immune cells can't respond to the virus because they're not hearing insulin”

“immune system programming is intimately connected with insulin signaling when we come insulin when we become insulin resistant our immune system does not work”

“and insulin resistance with covet outcomes imagine that”