Increased saturated fat intake in muscle tissue reduces glucose uptake by making the insulin signaling pathway less effective.

“in the muscle tissue when you increase your saturated fat intake when tissues when muscle cells start to increase their their uptake of saturated fat it D create it causes a post translational vacation to a particular protein known as IRS 1 which is insulin receptor substrate number 1 and when that happens the insulin receptor substrate number 1 undergoes a a protein modification that makes the entire insulin signaling pathway underneath it less effective”