Paul Saladino· MD
perhaps what we're seeing in many people who have high particle counts or I should say large numbers of small particles reflection of insulin resistance exactly
Loading…
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
perhaps what we're seeing in many people who have high particle counts or I should say large numbers of small particles reflection of insulin resistance exactly
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
as i will mention more in a moment i actually don't think small particles and ldl size are much of a cardiovascular disease risk marker when you are insulin sensitive or they're just an indicator that you might be insulin resistant in a lot of people but doesn't work that way for everyone
but it doesn't appear to be very clinically relevant right because remember it's all the burden of disease is from these they Poe be bearing particles and so the increase in the LDL particle number is not what's driving the risk of the disease
I can measure small dense LDL cholesterol HDL - cholesterol just small LDL particle concentration I can do an insulin level and ten other tests that tell me your insulin resistance oh I don't need any vol Markman they we're using that as part of their IR if you don't have that and they used a factor in VLDL size they're because the big triglyceride rich vldls or marker mints or resistance but if you're measuring insulin levels and other insulin biomarkers they're no better than that I don't know they're any better than just measuring small LDL particle concentration at least in a drug naive person
we used to say well the small VLDL P those are the remnants that's the mark well they don't do that anymore they only give you the large VLDL - P anymore those anymore generating labs that have the proprietary ability to release vo the L particle data and that's not all in them said as a lipo science lab core there's no more lipo scientist lab course so you will get a large VLDL p and it has one reason and one reason alone it's a lipoprotein marker of an insulin resistance state that's it it's not a goal of therapy it's nothing there's no data at of what you do to vo the LP effects comes although I'd make the case that maybe it does but it's just an IR marker
it's a lipoprotein marker of an insulin resistance state that's it it's not a goal of therapy it's nothing there's no data at of what you do to vo the LP effects comes although I'd make the case that maybe it does but it's just an IR marker
in insulin resistance where the vldl and kyos can't get rid of their trigs they then you these people have what is called increased remnants